Antifungal Activity of Extracellular Hydrolases Produced by Autolysing Aspergillus nidulans Cultures

作者：Szilagyi Melinda; Anton Fruzsina; Forgacs Katalin; Yu Jae Hyuk; Pocsi Istvan; Emri Tamas^*

来源：Journal of Microbiology, 2012, 50(5): 849-854.

DOI：10.1007/s12275-012-2001-0

• antifungal activity
• A. nidulans
• chitinase
• beta-1,3-glucanase
• proteinase

Carbon-starving Aspergillus nidulans cultures produce high activities of versatile hydrolytic enzymes and, among these, ChiB endochitinase and EngA beta-1,3-endoglucanase showed significant antifungal activity against various fungal species. Double deletion of engA and chiB diminished the antifungal activity of the fermentation broths and increased conidiogenesis and long-term viability of A. nidulans, but decreased the growth rate on culture media containing weak carbon sources. Production of ChiB and EngA can influence fungal communities either directly due to their antifungal properties or indirectly through their effects on vegetative growth. Our data suggest saprophytic fungi as promising future candidates to develop novel biocontrol technologies.

• 出版日期2012-10