A preliminary study to assess the impact of maternal age on stress-related variables in healthy nulliparous women

作者：Garcia Blanco Ana; Monferrer Alberto; Grimaldos Jorge; Hervas David; Balanza Martinez Vicent; Diago Vicente; Vento Maximo; Chafer Pericas Consuelo

来源：Psychoneuroendocrinology, 2017, 78: 97-104.

DOI：10.1016/j.psyneuen.2017.01.018

• Advanced maternal age
• Cortisol
• alpha-Amylase
• Stress
• Parenting

Purpose: Childbearing age has progressively increased in industrialized countries. The impact of this delay on motherhood, however, requires further research.
Methods: The study sample included a prospective cohort of healthy nulliparous pregnant women aged between 18 and 40 years (n = 148) assessed at 38 weeks gestation (Time#1, T1), 48 h after birth (Time#2, T2), and 3 months after birth (Time#3, T3). The effect of age on psychological, biological, and social variables was evaluated. Maternal psychological symptoms in terms of depression and anxiety were assessed at T1-T3; and parenting stress at T3. Stress biomarkers (cortisol, alpha-amylase) were determined in mothers at T1-T3. Questionnaires addressing social functioning (i.e., family functioning, maternal attitudes, and social support) were conducted at T3. Bayesian additive models were used to analyze the data.
Results: Depressive symptoms showed a steep increase starting from 35 years of age at T1 and an U-shaped relationship with a minimum around 30 years old at T3. The same results were observed for parenting stress. Cortisol levels increased sharply from 30 years of age at T3. Family functioning, maternal attitudes, and social support improved moderately from 30 years of age.
Conclusions: Prenatal depressive symptoms were higher in older women, but postpartum depressive symptoms and parenting stress increased in both younger and older women. Nevertheless, cortisol levels just increased in older ages at postpartum. In contrast, social functioning (family functioning, maternal attitudes, and social support) improved with age. We conclude that these social advantages may compensate for other disadvantages of delayed childbearing (i.e., depressive symptoms, parenting stress, and high cortisol level).

• 出版日期2017-4