A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions

作者：McGilvray Kirk C; Sarkar Rajabrata; Nguyen Khanh; Puttlitz Christian M^*

来源：Journal of Biomechanics, 2010, 43(15): 2941-2947.

DOI：10.1016/j.jbiomech.2010.07.012

• Biaxial stretch experiment
• Deep vein thrombosis (DVT)
• Strain energy function
• Post-phlebitic veins
• Biomechanics

Although biomechanical studies of the normal rat vein wall have been reported (Weizsacker, 1988; Plante, 2002), there are no published studies that have investigated the mechanical effects of thrombus formation on murine venous tissue. In response to the lack of knowledge concerning the mechanical consequences of thrombus resolution, distinct thrombus-induced changes in the biomechanical properties of the murine vena cava were measured via biaxial stretch experiments. These data served as input for strain energy SEF) fitting and modeling (Gasser et al., 2006). Statistical differences were observed between healthy and diseased tissue with respect to the structural coefficient that represents the response of the non-collagenous, isotropic ground substance. Alterations following thrombus formation were also noted for the SEF coefficient which describes the anisotropic contribution of the fibers. The data indicate ligation of the vena cava leads to structural alterations in the ground substance and collagen fiber network.

• 出版日期2010-11-16