科研之友
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摘要
ObjectiveMenopausal status may increase cardiovascular disease (CVD) risk. Nitric oxide plays a role in the protection against CVD onset and progression but has not been studied around the time of menopause. We investigated associations between serum nitric-oxide metabolite (NOx) concentrations and menopausal status. DesignComparative case-control cross-sectional study. SettingTehran Lipid and Glucose Study, university center. SampleSub-groups from a cohort of 2137 women, of whom 213 met enrollment criteria. MethodsWe studied four sub-groups in a 1.2 ratio: (1) post-menopausal women (n=29) with natural amenorrhea for 13-24months, (2) age- and BMI-matched controls (n=58) with regular menstrual cycles; (3) peri-menopausal women (n=42) with natural amenorrhea for 1-12months, and (4) age- and BMI-matched women as controls for the last group of women (n=84). Main outcome measureSerum nitric oxide concentrations. ResultsMedians (inter-quartile ranges) of NOx in post-menopausal women and their controls were 31 (21.7-40.2) and 23.5 (17.2-31) mol/L, respectively (p=0.012). In peri-menopausal women and their controls the medians (inter-quartile ranges) were 28mol/L (18.5-50.5) and 25 (20-31.25) mol/L, respectively (p=0.035), but were not significantly different between peri- and postmenopausal women and were unchanged after adjustment for lipids. In a conditional fixed-effect logistic regression model, the risk of transition to menopause and menopause rose respectively 2.44- and 2.27-fold for a one-score increase in the NOx standard deviation. ConclusionMenopausal status, by itself and not as a consequence of aging, is associated with increased serum nitric oxide concentrations. Identification of variables associated with menopausal cardiovascular consequences may be used to improve women's health after menopause.
- 出版日期2015-7
