A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods

作者：Maharani Rani; Brownlee Robert T C; Hughes Andrew B; Abbott Belinda M^*

来源：Tetrahedron, 2014, 70(14): 2351-2358.

DOI：10.1016/j.tet.2014.02.036

• Aureobasidin
• N-Methylated cyclodepsipeptide
• Depsidipeptide
• Fmoc-based solid-phase peptide synthesis

[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected residues including a depsidipeptide, Fmoc-MeVal-Hmp-OH, were prepared in solution phase. Chain elongation on chlorotrityl resin was undertaken using selected coupling reagents including HBTU/HOBt, HATU/HOAt and BTC/collidine. Cleavage of the linear depsinonapeptide was followed by cyclisation to give the desired cyclodepsipeptide.

• 出版日期2014-4-8