Associations between TNF-alpha Polymorphisms and Pneumonia: A Meta-Analysis

作者：Li, Li; Nie, Wei; Li, Weifeng; Yuan, Weifeng; Huang, Wenjie^*

来源：PLos One, 2013, 8(4): e61039.

DOI：10.1371/journal.pone.0061039

• COMMUNITY-ACQUIRED PNEUMONIA
• CYTOKINE EXPRESSION
• SEPSIS MORTALITY
• SEPTIC SHOCK
• IN-VITRO
• PROMOTER
• SUSCEPTIBILITY
• RISK

Background: Several studies evaluated the associations of tumor necrosis factor-alpha (TNF-alpha) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.
Methods: Databases including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Data were extracted independently by two investigators. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.
Results: Twelve case-control studies and one cohort study were included. Overall, no association between TNF-alpha -308A/G polymorphism and pneumonia risk was observed for AA +AG vs. GG (OR = 1.13; 95% CI 0.99-1.30; P = 0.07). In addition, TNF-alpha -308A/G polymorphism was not associated with pneumonia mortality (OR = 1.96; 95% CI 0.94-4.09; P = 0.07). Furthermore, there was no association of TNF-alpha -238A/G polymorphism with the risk of pneumonia (OR = 1.38; 95% CI 0.84-2.28; P = 0.20).
Conclusions: TNF-alpha -308A/G, -238A/G polymorphisms were not associated with pneumonia risk. Moreover, TNF-alpha -308A/G polymorphism did not play a role in the pneumonia mortality risk.

• 出版日期2013-4-8
• 单位中国人民解放军第二军医大学; 广州军区广州总医院; 天津市中医药研究院附属医院