A copper-catalyzed cascade reaction of o-bromoarylisothiocyanates with isocyanides leading to benzo[d]imidazo[5,1-b]thiazoles under ligand-free conditions

作者：Yan, Kelu; Yang, Daoshan^*; Wei, Wei; Sun, Pengfei; Lu, Yunxiang; Wang, Hua^*

来源：Organic Chemistry Frontiers, 2016, 3(5): 556-560.

DOI：10.1039/c6qo00030d

• OLIGOSUBSTITUTED PYRROLES
• ALPHA-ISOCYANOACETATES
• TANDEM REACTION
• BOND FORMATION
• ARYL HALIDES
• THIOLS
• SULFUR
• ACIDS
• CYCLOADDITION
• BENZOTHIOPHENES

A convenient and efficient copper-catalyzed domino method has been initially developed for the synthesis of benzo[d]imidazo[5,1-b]thiazole derivatives via the reactions of readily available substituted o-bromoarylisothiocyanates with isocyanides under ligand-free conditions. This chemistry involves intermolecular [3 + 2] cycloaddition and intramolecular Ullmann-type C-S bond formation.

• 出版日期2016
• 单位曲阜师范大学