Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer%26apos;s disease

作者：Sadigh Eteghad Saeed; Majdi Alireza; Mahmoudi Javad; Golzari Samad E J; Talebi Mahnaz

来源：Journal of Neural Transmission, 2016, 123(12): 1359-1367.

DOI：10.1007/s00702-016-1580-z

• Astrocyte
• Microglia
• Nicotinic acetylcholine receptors
• Alzheimer's disease

It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to A beta metabolism, including A beta phagocytosis and degradation as well as A beta-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-d-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis.

• 出版日期2016-12