A new N,N-bis(2-pyridylmethyl)methylamine iron(III) complex: synthesis, structure, DNA binding, and nuclease activity

作者：Qian Jing^*; Wang Liping; Tian Jinlei; Yan Shiping

来源：Journal of Coordination Chemistry, 2011, 64(18): 3256-3264.

DOI：10.1080/00958972.2011.602674

• Iron(III)
• Crystal structure
• DNA binding
• DNA cleavage

A new iron(III) complex, [Fe(bpma)Cl(3)] (1) (bpma N,N-bis(2-pyridylmethyl) methylamine), has been synthesized and determined by X-ray diffraction. Complex 1 crystallizes in the orthorhombic space group P(nma), with FeN(3)Cl(3) core, average d(Fe-N) of 2.212 angstrom, and average d(Fe-Cl) of 2.293 angstrom. Elemental analysis and infrared spectra of the complex were also determined. Complex 1 is soluble in water and organic solvents, facilitating investigation of its behavior in solution. Interaction with calf thymus-DNA (ct-DNA) for 1 investigated by UV absorption and fluorescence spectroscopy shows 1 binds to ct-DNA with moderate intercalation. The interaction between 1 and pBR322 DNA has also been investigated by submarine gel electrophoresis; the complex exhibits effective DNA cleavage activity in the absence of activating agents under similar physiological conditions.

• 出版日期2011
• 单位南开大学; 天津师范大学