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摘要
An efficient one-pot four-component reaction was developed for the synthesis of two different stereochemical classes of substituted 2-aminotetrahydroindoles from substituted -nitrostyrenes, cyclohexanones, ammonium acetate, and activated methylene compounds, such as Meldrum's acid, 4-hydroxycoumarin, cyclohexanediones, cyclopentane-1,3-dione, or alkyl cyanoacetates. Both electron-donating and electron-withdrawing groups are tolerated in the aryl ring of the -nitrostyrene. The reaction utilizes the triethylamine-promoted formation of new C-C and C-N bonds, and simultaneous aromatization in a domino fashion.
- 出版日期2016-4
- 单位扬州大学
