Phenyl vs. Ferrocenyl Cyclometallation Selectivity: Diastereoselective Synthesis of an Enantiopure Iridacycle

作者：Arthurs Ross A; Horton Peter N; Coles Simon J; Richards Christopher J^*

来源：European Journal of Inorganic Chemistry, 2017, 2017(2): 229-232.

DOI：10.1002/ejic.201600904

• Metallacycles
• Iridium
• Iron
• Sandwich complexes
• Regioselectivity
• Diastereoselectivity
• Chirality

Ferrocenyl (Fc) and phenyl (Ph) containing imines FcCH=NCH(R)Ph and FcCH(R)N=CHPh (R = H and Me) were cycloiridated using [Cp*IrCl2](2) with NaOAc in CH2Cl2. All resulted in the formation of neutral chloride ligated half-sandwich iridacycles as a result of ortho-phenyl and not alpha-ferrocenyl C-H activation. The complexes derived from FcCH=NCH(R)Ph (R = H, Me) were obtained as a mixture of E and Z imine isomers, and with R = Me the product obtained from the (S)-imine was isolated by recrystallisation as a single diastereoisomer. The configuration was determined by an X-ray crystal structure analysis as S-C,R-Ir,E.

• 出版日期2017-1