Associations between Polymorphisms in Genes Involved in Fatty Acid Metabolism and Dietary Fat Intakes

作者：Bouchard Mercier Annie; Paradis Ann Marie; Perusse Louis; Vohl Marie Claude^*

来源：Journal of Nutrigenetics and Nutrigenomics, 2012, 5(1): 1-12.

DOI：10.1159/000336511

• Dietary fat intakes
• Polymorphisms
• Appetite regulation
• PPAR alpha
• PPAR gamma
• PPAR delta
• PPARGC1 alpha
• FASN
• SREBF1

Background: Obesity prevalence is growing in our population. Twin studies have estimated the heritability of dietary intakes to about 30%. The objective of this study was to verify whether polymorphisms in genes involved in fatty acid metabolism are associated with dietary fat intakes. Methods: Seven hundred participants were recruited. A validated food frequency questionnaire was used to assess dietary intakes. PCR-RFLP and TAQMAN methodology were used to genotype PPAR alpha Leu162Val, PPAR gamma Pro12Ala, PPAR delta -87T %26gt; C, PPARGC1 alpha Gly482Ser, FASN Val1483Ile and SREBF1 c.*619C %26gt; G. Statistical analyses were executed with SAS statistical package. Results: Carriers of the Ala12 allele of PPAR gamma Pro12Ala polymorphism had higher intakes of total fat (p = 0.04). For FASN Val1483Ile polymorphism, significant gene-sex interaction effects were found for total fat and saturated fat intakes (p = 0.02 and p = 0.002, respectively). No significant difference in fat intakes was observed for PPAR alpha Leu162Val, PPAR delta -87T %26gt; C, PPARGC1 alpha Gly482Ser and SREBF1 c.*619C %26gt; G polymorphisms. Conclusions: Polymorphisms in PPAR gamma and FASN seem to be associated with dietary fat intakes. Genetic variants are important to take into account when studying dietary intakes.

• 出版日期2012