Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst

作者：Safari Javad^*; Banitaba Sayed Hossein; Khalili Shiva Dehghan

来源：Ultrasonics Sonochemistry, 2012, 19(5): 1061-1069.

DOI：10.1016/j.ultsonch.2012.01.005

• 2-Amino-4,6-diphenylnicotinonitriles
• Multicomponent reactions
• Ultrasonic irradiation
• Green chemistry
• Water

A green and convenient approach to the synthesis of 2-amino-4,6-diphenylnicotinonitriles via four-component reaction of malononitrile, aromatic aldehydes, acetophenone derivatives and ammonium acetate in water under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this sonocatalyzed procedure.

• 出版日期2012-9