Natural variability in enantiomeric composition of bioactive chiral terpenoids in the essential oil of Solidago canadensis L. from Uttarakhand, India

作者：Chanotiya Chandan S^*; Yadav Anju

来源：Natural Product Communications, 2008, 3(2): 263-266.

• solidago canadensis L.
• Asteraceae
• chiral terpenoid
• essential oil composition
• (+)-germacrene D
• enantiomeric excess

The natural variability in the enantiomeric distribution of biologically active chiral terpenoids in Solidago canadensis L. essential oil from Kumaon was evaluated by enantioselective capillary GC, capillary GC, and GC-MS. Germacrene D, a sesquiterpene hydrocarbon, was noticed as the major compound, contributing 56.7%, 75.5% and 69.7% to the samples, while other constituents with variable compositions were limonene (0.2 to 12.5%), bornyl acetate (2.1 to 2.9%), delta-elemene (2.4 to 3.2), beta-elemene (1.3 to 1.8%), and elemol (1.4 to 2.6%). The enantiomeric excess has been determined for germacrene D with (+)-enantiomer (> 41.8% to > 47%) dominating over the (-)-enantiomer in all the samples. Furthermore, there has been above 95% enantiomeric excess for (R)-(+)-limonene (> 95.1% to > 99%), whereas moderate to low excess for (1R)-(+)-alpha-pinene (> 47.9%), and (1S)-(-)-beta-pinene (> 30.3%) was established. Notably, only (-)-bornyl acetate was found as a single enantiomer with > 99% enantiomeric excess. However, for all the identified chiral terpenoids, the enantiomeric distribution varied within only a narrow range in all the samples.

• 出版日期2008
• 单位河北医科大学