Mechanical insufflation/exsufflation improves vital capacity in neuromuscular disorders

作者：Stehling Florian^*; Bouikidis Anastasios; Schara Ulrike; Mellies Uwe

来源：Chronic Respiratory Disease, 2015, 12(1): 31-35.

DOI：10.1177/1479972314562209

• Neuromuscular disorders
• lung function
• vital capacity
• mechanical insufflation
• exsufflation

Inherited neuromuscular disorders inevitably result in severe lung volume restriction associated with high morbidity and mortality. The aim of this retrospective study was to evaluate the long-term effects of the regular use of mechanical insufflation/exsufflation on the course of the vital capacity. This retrospective data analysis included 21 patients (16.1 +/- 6.5 years) with neuromuscular disorders and severe lung volume restriction using nocturnal noninvasive ventilation. The patients were advised to regularly use the mechanical insufflation/exsufflation twice a day for 10 minutes applying sets of three insufflation/exsufflation breath via face mask irrespective of respiratory tract infection. Data on the course of vital capacity were collected 2 years prior and 2 years after the introduction of regular use of mechanical insufflation/exsufflation. Before the introduction of mechanical insufflation/exsufflation vital capacity decreased from 0.71 +/- 0.38 L to 0.50 +/- 0.24 L in the last year and from 0.88 +/- 0.45 L to 0.71 +/- 0.38 L in the next to last year. In the first year, after regular use of mechanical insufflation/exsufflation vital capacity significantly increased by 28% (from 0.50 L to 0.64 L)after the second year the vital capacity increase remained stable (0.64 vs. 0.65 L). These data suggest that the regular use of mechanical insufflation/exsufflation improves vital capacity in patients with neuromuscular disorders and severe lung volume restriction.

• 出版日期2015-2