Neuromyelitis optica spectrum disorders without and with autoimmune diseases

作者：Zhang, Bingjun; Zhong, Yi; Wang, Yanqiang; Dai, Yongqiang; Qiu, Wei; Zhang, Lei; Li, Haiyan; Lu, Zhengqi^*

来源：BMC Neurology, 2014, 14(1): 162.

DOI：10.1186/s12883-014-0162-7

• Neuromyelitis optica
• Neuromyelitis optica spectrum disorder
• Non-organ-specific autoimmune diseases
• Organ-specific autoimmune diseases
• Autoantibodies
• Magnetic resonance imaging

Background: Neuromyelitis optica spectrum disorder (NMOSD) can coexist with non-organ-specific or organ-specific autoimmune diseases. The aim of this study was to investigate and compare the features between NMOSD without and with autoimmune diseases, and NMOSD with non-organ-specific and organ-specific autoimmune diseases. @@@ Methods: One hundred and fifty five NMOSD patients without autoimmune diseases (n = 115) and with autoimmune diseases (n = 40) were enrolled. NMOSD with autoimmune diseases were divided by organ-specific autoimmune diseases. The clinical, laboratory and magnetic resonance imaging features between two groups were assessed. @@@ Results: Motor deficit was less frequent in NMOSD patients with non-organ-specific autoimmune diseases (p = 0.024). Cerebrospinal fluid white blood cell and protein, serum C-reactive protein and immunoglobulin G were lower in NMOSD patients without autoimmune diseases, while several autoantibodies seropositivity and thyroid indexes were significantly higher in NMOSD patients with autoimmune diseases (p < 0.05). No difference was found in other clinical and laboratory characteristics between different NMOSD subtypes (p > 0.05). NMOSD patients with autoimmune diseases had higher brain abnormalities than NMOSD without autoimmune diseases (p < 0.001). @@@ Conclusions: The characteristics between NMOSD without and with autoimmune diseases were similar. NMOSD with autoimmune diseases have high frequency of brain abnormalities.

• 出版日期2014-8-19
• 单位中山大学