Associations of leukocyte telomere length with body anthropometric indices and weight change in chinese women

作者：Cui Yong; Gao Yu Tang; Cai Qiuyin; Qu Shimian; Cai Hui; Li Hong Lan; Wu Jie; Ji Bu Tian; Yang Gong; Chow Wong Ho; Shu Xiao Ou; Zheng Wei^*

来源：Obesity, 2013, 21(12): 2582-2588.

DOI：10.1002/oby.20321

Objective: This study evaluated associations of telomere length with various anthropometric indices of general and abdominal obesity, as well as weight change. Design and Methods: The study included 2,912 Chinese women aged 40-70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative telomere length. Results: Telomere length was inversely associated with body mass index (BMI), waist circumference, waist-to-height ratio, weight, and hip circumference (Ptrend = 0.005, 0.004, 0.004, 0.010, and 0.026, respectively), but not waist-to-hip ratio (Ptrend = 0.116) or height (Ptrend = 0.675). Weight change since age 50 was further evaluated among women over age 55. Women who maintained their weight within +/- 5% since age 50, particularly within a normal range (BMI = 18.5-24.9 kg/m2), or reduced their weight from overweight (BMI = 25-29.9 kg/m2) or obesity (BMI 30 kg/m2) to normal range, had a longer mean of current telomere length than women who gained weight since age 50 (Ptrend = 0.025), particularly those who stayed in obesity or gained weight from normal range or overweight to obesity (P = 0.023). Conclusion: Our findings show that telomere shortening is associated with obesity and that maintaining body weight within a normal range helps maintain telomere length.

• 出版日期2013-12
• 单位上海市肿瘤研究所