Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats

作者：Martins Pucci Karla Roberta; Pereira Junior Carlos Donizete; Idalo Priscila Barbosa; Santana Pinheiro Moreira Ana Carolina; Rocha Laura Penna; Aquiles Rodrigues Aldo Rogelis; dos Reis Luiz Carlos; da Silva Gomes Roseli A; Rocha Lenaldo Branco; de Oliveira Guimaraes Camila Souza; dos Reis Marlene Antonia; Saraiva Camara Niels Olsen; Miranda Correa Rosana Rosa

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2015, 28(4): 403-408.

DOI：10.3109/14767058.2014.918097

• Diabetes
• folic acid-induced renal failure
• kidney morphology
• morphometry
• pregnancy

Objective: To evaluate the effects of folic acid (FA)-induced renal failure in young offspring of diabetic mothers.
Methods: The offspring of streptozotocin-induced diabetic dams were divided into four groups: CC (controls receiving vehicle); DC (diabetics receiving vehicle); CA (controls receiving FA solution, 250 mg/kg) and DA (diabetics receiving FA solution, 250 mg/kg). Renal function tests and morphometry results were analyzed.
Results: An increase in creatinine and urea levels was observed in CA and DA groups at two and five months. FA administration caused a significant reduction in the number of glomeruli in the offspring of diabetic dams. The diabetes group treated with FA had fewer glomeruli compared to controls at two and five months. FA caused an increase in the area of the urinary space both in controls and offspring of diabetic dams at two and five months. The number of glomeruli and area of the urinary space at two months were negatively correlated.
Conclusions: Fetal programing promotes remarkable changes in kidney morphology and function in offspring. We suggest that the morphological changes in the kidneys are more pronounced when fetal programing is associated with newly acquired diseases, e.g. renal failure induced by FA.

• 出版日期2015-3