Potentiometric detection of DNA hybridization

作者:Numnuam Apon; Chumbimuni Torres Karin Y; Xiang Yun; Bash Ralph; Thavarungkul Panote; Kanatharana Proespichaya; Pretsch Ernoe*; Wang Joseph; Bakker Eric
来源:Journal of the American Chemical Society, 2008, 130(2): 410-+.
DOI:10.1021/ja0775467

摘要

The use of potentiometric microsensors is demonstrated here for the first time to detect DNA hybridization. Cadmium sulfide nanocrystal labels bound on a secondary oligonucleolide are dissolved and detected with cadmium-selective microelectrodes exhibiting DNA detection limits of ca. 2 fmol in a 200 mu sample.

  • 出版日期2008-1-16