Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques

作者：de Groot Natasja G^*; Heijmans Corrine M C; de Ru Arnoud H; Hassan Chopie; Otting Nel; Doxiadis Gaby G M; Koning Frits; van Veelen Peter A; Bontrop Ronald E

来源：Immunogenetics, 2013, 65(12): 897-900.

DOI：10.1007/s00251-013-0734-5

• Rhesus macaque
• HIV
• HLA
• MHC peptidomics
• Polymorphism
• Supertype

Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.

• 出版日期2013-12