ANALYSIS OF THE 5' FLANKING SEQUENCE OF THE G-GAMMA GLOBIN GENE BY DENATURING GRADIENT GEL-ELECTROPHORESIS CONFIRMS THE HETEROGENEITY OF THE BANTU BETA-S HAPLOTYPE

作者：TACHDJIAN G^*; BENABDENNEBI M; GUIDAL C; SAYADA C; LAPOUMEROULIE C; ELION J

来源：Human Genetics, 1992, 90(1-2): 23-26.

The GC --> TT polymorphism recently described at positions -1106 and -1105 in the 5' flanking region of the Ggamma globin gene for the Bantu beta(S) haplotype was analysed by denaturing gradient gel electrophoresis. We studied 108 beta(S) chromosome and 122 beta(A) chromosomes. The TT sequence was found as follows: in all of 80 chromosomes bearing the Bantu beta(S) haplotype with the 6-bp deletion -400 nt from the Ggamma gene in 3 out of 5 Bantu beta(S) chromosomes without the deletion, in 1 out of 122 beta(A) chromosomes from different ethnic origins but in none of 23 beta(S) chromosomes bearing the Senegal, Benin or Cameroon haplotypes. These results confirm the heterogeneity of the Bantu beta(S) haplotype and allow a tentative evolutionary sequence for the different alleles at this locus to be presented.

• 出版日期1992-10