Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy

作者：Komatsu Shuichi; Hara Noboru^*; Ishizaki Fumio; Nishiyama Tsutomu; Takizawa Itsuhiro; Isahaya Etsuko; Kawasaki Takashi; Takahashi Kota

来源：Prostate, 2012, 72(11): 1207-1213.

DOI：10.1002/pros.22471

• interleukin-6
• androgen deprivation therapy
• sex steroids
• %body fat

BACKGROUND Interleukin-6 produced in adipose tissue plays a role in lipid metabolism, and also interacts with sex steroids. This study was performed to elucidate the mechanism of lipid metabolism disorder during androgen deprivation therapy (ADT) in terms of the association of interleukin-6 with sex steroids. METHODS Seventy-two patients with localized prostate cancer were prospectively studied based on their body-composition and blood samples before and after ADT for 6 months. RESULTS Before ADT, serum interleukin-6 levels were inversely correlated with serum total-testosterone (rs?=?-0.305, P?=?0.009) and dihydrotestosterone (rs?=?-0.380, P?=?0.006) concentrations, but not correlated with adrenal androgen or estradiol levels. Pretreatment interleukin-6 levels were positively correlated with %body fat (rs?=?0.349, P?=?0.003) and %visceral fat (rs?=?0.384, P?=?0.001). After ADT, %body fat increased (P?%26lt;?0.001) and lean body mass decreased (P?=?0.036). After ADT, in contrast to the pretreatment relationship, interleukin-6 levels were positively correlated with total-testosterone concentrations (rs?=?0.343, P?=?0.003), and were positively correlated also with levels of androstenedione (rs?=?0.351, P?=?0.002) and estoradiol (rs?=?0.335, P?=?0.004). Interleukin-6 levels were equivalent between before and after ADT (2.02 vs. 2.16?pg/ml, P?=?0.205), but the positive correlation between interleukin-6 levels and %body or %visceral fat noted before ADT disappeared after ADT. CONCLUSIONS Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. The altered association between interleukin-6 and sex steroids is possibly involved in ADT-related lipid metabolism disorder with unchanged interleukin-6 levels despite increased %body fat. Prostate 72:12071213, 2012.

• 出版日期2012-8