Applications of DNAzymes in the Detection of Heavy Metal Ions

作者：Li Hui; Kong Deming^*

来源：Progress in Chemistry, 2013, 25(12): 2119-2130.

• DNAzyme
• metal ions
• sensors
• fluorescent sensors
• colorimetric sensors

DNAzymes, obtained by in vitro screening technique (systematic evolution of ligands by exponential enrichment, SELEX technique), are single-stranded DNAs with enzymatic activities. Compared to natural enzymes, DNAzymes are superior in terms of stability, ease of synthesis, modification and storage. As for some DNAzymes, they need specific metal ions as cofactors, and their enzymatic activities are highly dependent on the metal ion concentration. Their applications in metal ions detection have attracted more and more attention in these years. In this review, we summarized the researches on DNAzyme-based metal ion sensors. The focus is on the design of fluorescent sensors and colorimetric sensors.

• 出版日期2013-12-24
• 单位南开大学