Phytotherapeutics in cancer invasion and metastasis

作者：Salehi Bahare; Zucca Paolo; Sharifi Rad Mehdi; Pezzani Raffaele; Rajabi Sadegh; Setzer William N; Varoni Elena Maria; Iriti Marcello^*; Kobarfard Farzad; Sharifi Rad Javad^*

来源：Phytotherapy Research, 2018, 32(8): 1425-1449.

DOI：10.1002/ptr.6087

• adjuvant therapy
• anticancer drugs
• cancer chemoprevention
• chemotherapy
• phytochemicals
• plant products

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

• 出版日期2018-8