A wide-band bio-chip for real-time optical detection of bioelectromagnetic interactions with cells

作者：Merla Caterina^*; Liberti Micaela; Marracino Paolo; Muscat Adeline; Azan Antoine; Apollonio Francesca; Mir Lluis M

来源：Scientific Reports, 2018, 8(1): 5044.

DOI：10.1038/s41598-018-23301-w

The analytical and numerical design, implementation, and experimental validation of a new grounded closed coplanar waveguide for wide-band electromagnetic exposures of cells and their optical detection in real-time is reported. The realized device fulfills high-quality requirements for novel bioelectromagnetic experiments, involving elevated temporal and spatial resolutions. Excellent performances in terms of matching bandwidth (less than -10 dB up to at least 3 GHz), emission (below 1 x 10(-6) W/m(2)) and efficiency (around 1) have been obtained as revealed by both numerical simulations and experimental measurements. A low spatial electric field inhomogeneity (coefficient of variation of around 10 %) has been achieved within the cell solutions filling the polydimethylsiloxane reservoir of the conceived device. This original bio-chip based on the grounded closed coplanar waveguide concept opens new possibilities for the development of controlled experiments combining electromagnetic exposures and sophisticated imaging using optical spectroscopic techniques.

• 出版日期2018-3-22