Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome

作者：Santangelo Andrea; Bortolato Marco; Mosher Laura J; Crescimanno Giuseppe; Di Giovanni Giuseppe; Cassioli Emanuele; Ricca Valdo; Casarrubea Maurizio^*

来源：CNS Neuroscience & Therapeutics, 2018, 24(8): 703-711.

DOI：10.1111/cns.12789

• D1CT-7
• mice
• tic disorders
• Tourette's syndrome
• T-pattern analysis
• transition matrices

AimThe transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS.
MethodsThe behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics.
ResultsT-patterns and transition matrices revealed in D1CT-7 mice a clear-cut hyperactivity compared to controls, with a lower behavioral organization and a marked shift from cautious sniffing toward locomotion. Moreover, the behavioral patterns of the transgenic mice were pervasively disturbed by intrusive tic-like HBT leading to a marked fragmentation of the behavior. Novel exposure to open field provoked a transient inhibitory control over the disrupting phenotype.
ConclusionThe results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.

• 出版日期2018-8