Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes

作者：Gao, Shang; Liu, Hao; Yang, Chi; Fu, Zhiyuan; Yao, Hequan^*; Lin, Aijun^*

来源：Organic Letters, 2017, 19(18): 4710-4713.

DOI：10.1021/acs.orglett.7b01960

• INTERNAL ALKYNES
• C-C
• DIENES
• ZAMPANOLIDE
• CYCLIZATION
• ALLYLATION
• 1,4-DIENES
• COMPLEXES
• BUTADIENE
• ACRYLATES

An unprecedented palladium-catalyzed allylic alkylation of pronucleophiles with unactivated skipped enynes has been developed. This method provides a straightforward access to a-wide array of 1,3-dienes without the need to preinstall leaving groups or employ extra oxidants. The reaction exhibited high atom, economy, good functional group tolerance, excellent regioselectivities, and scalability. With D2O as cosolvent, deuterium could be incorporated in high efficiency.

• 出版日期2017-9-15
• 单位中国药科大学