Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

作者：Nasongkla Norased; Bey Erik; Ren Jimin; Ai Hua; Khemtong Chalermchai; Guthi Jagadeesh Setti; Chin Shook Fong; Sherry A Dean; Boothman David A; Gao Jinming^*

来源：Nano Letters, 2006, 6(11): 2427-2430.

DOI：10.1021/nl061412u

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide ( SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.