Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities

作者：Zhang, Bao-Bao; He, Bai-Qiu; Sun, Jian-Bo; Zeng, Biao; Shi, Xiao-Ji; Zhou, Yong; Niu, Ying; Nie, Shi-Qi; Feng, Feng; Liang, Yan^*; Wu, Fei-Hua

来源：Molecules, 2015, 20(8): 14879-14888.

DOI：10.3390/molecules200814879

• Salvia plebeia
• diterpenoids
• antioxidant activity
• anti-inflammatory activity

A new skeleton of diterpenoid, 1,2,3,4,4,9,10,10-octahydro-(4-hydroxyymethyl)-1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4R,9R,10S)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2-5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0-29.6 mu M. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1-3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0-23.6 mu M. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation.

• 出版日期2015-8
• 单位中国药科大学