Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area

作者：Gavrilov Yury V; Ellison Brian A; Yamamoto Mihoko; Reddy Hasini; Haybaeck Johannes; Mignot Emmanuel; Baumann Christian R; Scammell Thomas E; Valko Philipp O^*

来源：SLEEP, 2016, 39(5): 1059-1062.

DOI：10.5665/sleep.5754

• galanin
• narcolepsy
• sleep fragmentation
• ventrolateral preoptic area

Study Objectives: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients.
Methods: Postmortem examination of five narcolepsy and eight control brains.
Results: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 +/- 3,656) and controls (13,526 +/- 9,544).
Conclusions: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

• 出版日期2016-5-1