New York Heart Association class versus amino-terminal pro-B type natriuretic peptide for acute heart failure prognosis

作者：Baggish Aaron L^*; van Kimmenade Roland R J; Pinto Yigal; Richards A Mark; Lainchbury John; Bayes Genis Antoni; Santalo Miquel; Ordonez Llanos Jordi; Januzzi James L

来源：Biomarkers, 2010, 15(4): 307-314.

DOI：10.3109/13547501003632580

• Acute decompensated heart failure
• NYHA
• prognosis
• NT-proBNP
• natriuretic peptides

Background: The prognostic value of the New York Heart Association classification (NYHAC) in acutely decompensated heart failure (ADHF) is unknown.
Objectives: We sought to determine the relative value of NYHAC among patients with concomitantly measured amino-terminal pro-B type natriuretic peptide (NT-proBNP) at presentation with ADHF.
Materials and methods: NYHAC was determined for 720 patients with ADHF and 1-year mortality status was examined. Cox-proportional hazards analysis compared the prognostic accuracy of NYHAC with other ADHF risk measures.
Results: NYHAC had a significant univariate association with 1-year mortality status (HR 1.41, 95% confidence interval (CI) 1.03-1.94; p = 0.03) but was not a significant predictor of death in a multivariable model that included NT-proBNP (HR 2.14; 95% CI 1.65-2.81, p<0.001).
Conclusions: In contrast to objective measures such as NT-proBNP, the NYHAC appears to provide limited prognostic information among individuals with ADHF.

• 出版日期2010-6