Anti-allergic Flavones from Arthraxon hispidus

作者：Quan, Gui-Hua; Chae, Hee-Sung; Song, Hyuk Hwan; Ahn, Kyoung-Seop; Lee, Hyeong-Kyu; Kim, Young-Ho; Oh, Sei-Ryang^*; Chin, Young-Won

来源：Chemical & Pharmaceutical Bulletin, 2013, 61(9): 920-926.

• Arthraxon hispidus
• flavonoid
• bone-marrow derived mast cell
• interleukin-6
• leukotriene C-4
• prostaglandin D-2

Bioactivity-guided fractionation for an EtOAc-soluble fraction of methanolic extract of Arthraxon hispidus, using primary cell assay with bone marrow-derived mast cells (BMMC), led to an isolation of six new flavones and nine known compounds. The structures of the new compounds were established by one dimensional (1D)- and 2D-NMR spectroscopic data, as luteolin 8-C-beta-kerriopyranoside (1), luteolin 8-acetic acid methyl ester (2), 7-methyl-luteolin 8-C-beta-(6-deoxyxylo-3-uloside) (3), apigenin 8-C-alpha-fucopyranoside (4), apigenin 8-C-beta-fucopyranoside (5) and luteolin 8-C-beta-fucopyranoside (6). All the isolates were evaluated for inhibitory activities on interleukin-6 release in the primary cultures using BMMC. Of the tested compounds, compounds 2, 3 and 10 were found to inhibit interleukin-6 release. Furthermore, compound 2 displayed inhibitory activity against prostaglandin D-2 leukotriene C-4, and beta-hexosaminidase releases.

• 出版日期2013-9
• 单位吉林大学