A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing

作者：Ishiguro Kei ichiro; Kim Jihye; Fujiyama Nakamura Sally; Kato Shigeaki; Watanabe Yoshinori^*

来源：EMBO Reports, 2011, 12(3): 267-275.

DOI：10.1038/embor.2011.2

• cohesin
• meiosis
• chromosome segregation
• homologue synapsis
• centromere

We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.

• 出版日期2011-3