Does preeclampsia have any adverse effect on fetal heart?

作者：Akil Aybala^*; Api Olus; Can Esra Oten; Ozkan Sadullah; Ercan Serif; Orcun Asuman; Unal Orhan

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2016, 29(14): 2312-2315.

DOI：10.3109/14767058.2015.1085013

• Blood marker
• cardiac cell injury
• fetal
• fetal heart
• homocysteine
• neonatal
• NT-proBNP
• preeclampsia

Objective: To determine whether preeclampsia causes fetal cardiac cell damage by assessing umbilical artery NT-proBNP, cardiac troponin I and homocysteine.
Methods: A cross-sectional study with 73 fetuses between 26 and 40 weeks of gestation was performed. Thirty-three healthy mothers' fetuses were control group (Group I). While 12 mildly pre-eclamptic mothers' fetuses constituted Group II, 28 fetuses of severe pre-eclamptic mothers were Group III.
Results: Umbilical cord mean NT-proBNP levels of Group I, II and III are 520.8 +/- 404.5 pg/ml; 664.2 +/- 215.9 pg/ml; and 1932.8 +/- 2979.5 pg/ml, respectively (p = 0.0001). The number of neonates with NT-proBNP > 500 pg/mL that indicates severe cardiac damage is higher in Group III (p = 0.001). The mean homocysteine levels are also statistically significantly higher in Group III. Cardiac troponin I levels are not different between the groups (p = 0.46).
Conclusion: Increased NT-proBNP and homocysteine might not only indicate some degree of in-utero cardiac cell damage but also feto-placental endothelial injury in the fetuses of severe pre-eclamptic mothers. Our finding that shows no evidence of correlation between cardiac troponin I levels with cell damage and endothelial injury requires further research.

• 出版日期2016