Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance

作者：Dong, Ruijuan; Yuan, Jiuzhi; Wu, Shilong; Huang, Jian; Xu, Xiaotong; Wu, Zhaohua^*; Gao, Huiyuan

来源：Phytochemistry, 2015, 117: 325-331.

DOI：10.1016/j.phytochem.2015.06.025

• Caesalpinia minax Hance
• Caesalpinia
• A-seco-rearranged cassane
• Anti-inflammation activity
• Circular dichroism
• Conformation analysis

Cassane skeletons are rare in nature, but often possess valuable medicinal properties. A furanoditerpenoid with an unusual A-seco-rearranged cassane skeleton, neocaesalminin A, and five furanoditerpenoids were isolated from seeds of Caesalpinia minax Hance, along with six known cassane derivatives, 7-O-acetyl-bonducellpin C, caesalmin F, caesalmin C, zeta-caesalmin E1 and caesalpinin K. Compound structures were determined by spectroscopy (HR-ESI-MS, UV, IR, 1D NMR, 2D NMR), X-ray crystallography and quantum chemical computation of electronic circular dichroism). Three of the previously known compounds exhibited significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).

• 出版日期2015-9
• 单位牡丹江医学院; 沈阳药科大学