Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer

作者：Phipps Amanda I; Newcomb Polly A; Garcia Albeniz Xabier; Hutter Carolyn M; White Emily; Fuchs Charles S; Hazra Aditi; Ogino Shuji; Nan Hongmei; Ma Jing; Campbell Peter T; Figueiredo Jane C; Peters Ulrike; Chan Andrew T^*

来源：Gastroenterology, 2012, 143(1): 51-U555.

DOI：10.1053/j.gastro.2012.04.052

• Colon Cancer
• Genetic
• GWAS
• Prognosis

Genome-wide Association Studies Have Identified 16 Germline Single-nucleotide Polymorphisms (snps) That Are Associated With Colorectal Cancer (crc) Incidence. We Examined The Relationship Between These Snps And Survival Of 2611 Individuals With Crc, Enrolled In 5 Cohort Studies. We Used Cox Regression Analysis To Associate Snps With Overall And Crc-specific Survival Times. The Minor Allele In Rs4939827 (smad7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P = .002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.

• 出版日期2012-7