Neuroactive steroids and the peripheral nervous system: An update

作者:Giatti Silvia; Romano Simone; Pesaresi Marzia; Cermenati Gaia; Mitro Nico; Caruso Donatella; Tetel Marc J; Garcia Segura Luis Miguel; Melcangi Roberto C
来源:Steroids, 2015, 103: 23-30.
DOI:10.1016/j.steroids.2015.03.014

摘要

In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions. Indeed, neuroactive steroids have been recently proposed as therapies for different types of peripheral neuropathy, like for instance those occurring during aging, chemotherapy, physical injury and diabetes. Moreover, pharmacological tools able to increase the synthesis of neuroactive steroids might represent new interesting therapeutic strategy to be applied in case of peripheral neuropathy.

  • 出版日期2015-11