Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells

作者：Zhao Shuai; Kanno Yuichiro^*; Nakayama Momoka; Makimura Minami; Ohara Shiori; Inouye Yoshio

来源：Cancer Letters, 2012, 317(2): 192-198.

DOI：10.1016/j.canlet.2011.11.025

• Aryl hydrocarbon receptor
• Cancer stem cells
• Breast cancer

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/beta-catenin and Notch.

• 出版日期2012-4-28