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摘要
Purpose of review
To describe the difficulty in assessing the biological activity of a novel agent in phase II trials.
Recent findings
Two major fields of research provide interesting new potential endpoints: endpoints based on new imaging techniques (e.g. PET or spectral imaging that explore tumour metabolism, dynamic contrast enhanced (DCE) ultrasonography or DCE-MRI that explore tumour vascularization and tumour growth inhibition) and endpoints integrating assessment of tumour burden across time, such as the growth modulation index.
Summary
Most of the recently described techniques appear attractive, but require formal validation.
- 出版日期2012-5
