Activity of Fosfomycin against Extended-Spectrum-beta-Lactamase-Producing Uropathogens in Patients in the Community and Hospitalized Patients

作者：Linsenmeyer Katherine^*; Strymish Judith; Weir Susan; Berg Gretchen; Brecher Stephen; Gupta Kalpana

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(2): 1134-1136.

DOI：10.1128/AAC.02614-15

Few oral antibiotics exist for the empirical treatment of extended-spectrum beta-lactamase (ESBL) urinary tract infections (UTI). In this study, we sought to determine the activity of fosfomycin against ESBL-producing uropathogens from patients at 3 Veterans Affairs (VA) facilities between 2010 and 2013. Among the ESBL uropathogens, 19.9% were fosfomycin resistant. Klebsiella species were more likely than Escherichia coli to be resistant (46% versus 4%; P < 0.001). Fosfomycin remains active against a majority of the ESBL uropathogens, although resistance among Klebsiella spp. was higher than that in previous reports.

• 出版日期2016-2