Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia

作者：Nousome Darryl; Lupo Philip J; Okcu M Fatih; Scheurer Michael E^*

来源：Leukemia Research, 2013, 37(5): 531-535.

DOI：10.1016/j.leukres.2013.01.020

• Acute lymphoblastic leukemia
• Case-parent triad
• Haplotypes
• Xenobiotic metabolism

Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood ALL among 120 case-parent triads. Two of the five haplotypes were significantly associated with risk: GSTM3/GSTM4 (P = 0.01) and GSTP1 (P = 0.02). The EPHX1 haplotype was marginally associated with risk (P = 0.05), whereas haplotypes in CYP1B1 and GSTA4 were not. Our results suggest genetic variation in xenobiotic metabolism is important in childhood ALL etiology.

• 出版日期2013-5