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摘要
A series of novel 7,9-dihydrothieno[3,2:5,6]pyrido[2,3-d]pyrimidine-4,6(3H,5H)-dione derivatives were synthesized efficiently via the catalyst-free reaction of aldehyde, ethyl 2,4-dioxotetrahydrothiophene-3-carboxylate, and 2,6-diaminopyrimidine-4(3H)-one through the sequence of deethoxycarbonylation and three-component condensation in aqueous media. This protocol featured mild reaction conditions, high yields, easy work-up, and environmentally friendly procedure.
- 出版日期2014-8
- 单位江苏师范大学
