Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

作者：Ghita Adrian; Pascut Flavius C; Sottile Virginie; Notingher Ioan^*

来源：Analyst, 2014, 139(1): 55-58.

DOI：10.1039/c3an01716h

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

• 出版日期2014