Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria

作者：Su Chung Ren; Chen Yuh Fung; Liou Meei Jen; Tsai Huei Yann; Chang Wen Shin; Wu Tian Shung^*

来源：Bioorganic & Medicinal Chemistry, 2008, 16(21): 9603-9609.

DOI：10.1016/j.bmc.2008.09.023

• Fibraurea tinctoria Lour
• Furanoditerpenoids
• Anti-inflammatory activities

Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as. fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 mu g/ml).

• 出版日期2008-11-1
• 单位中国医科大学