Mechanisms of Reward Circuit Dysfunction in Psychiatric Illness: Prefrontal-Striatal Interactions

作者：Pujara Maia; Koenigs Michael^*

来源：The Neuroscientist, 2014, 20(1): 82-95.

DOI：10.1177/1073858413499407

• reward
• prefrontal cortex
• striatum
• addiction
• depression

The brain's reward circuit has been widely implicated in the pathophysiology of mental illness. Although there has been significant progress in identifying the functional characteristics of individual nodes within the circuit and linking dysfunction of these brain areas to various forms of psychopathology, there remains a substantial gap in understanding how the nodes of the circuit interact with one another, and how the growing neurobiological knowledge may be applied to improve psychiatric patient care. In this article, we summarize what is currently known about the functions and interactions of two key nodes of this circuitthe ventral striatum and the ventromedial prefrontal/orbital frontal cortexin relation to mental illness.

• 出版日期2014-2