Advances in regenerative therapies for spinal cord injury: a biomaterials approach

作者：Tsintou Magdalini; Dalamagkas Kyriakos; Seifalian Alexander Marcus^*

来源：Neural Regeneration Research, 2015, 10(5): 726-742.

DOI：10.4103/1673-5374.156966

• tissue engineering
• neuroregeneration
• repair
• central nervous system
• biomaterial
• regenerative medicine
• nanotechnology
• spinal cord injury

Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mechanism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing research interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaffold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. Here we review the recent advances on regenerative/neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction.

• 出版日期2015-5