A quadrivalent HPV vaccine induces humoral and cellular immune responses in WHIM immunodeficiency syndrome

作者：Handisurya Alessandra; Schellenbacher Christina; Reininger Baerbel; Koszik Frieder; Vyhnanek Philipp; Heitger Andreas; Kirnbauer Reinhard; Foerster Waldl Elisabeth

来源：Vaccine, 2010, 28(30): 4837-4841.

DOI：10.1016/j.vaccine.2010.04.057

• Human papillomavirus
• Vaccination
• Immunodeficiency
• WHIM-syndrome

WHIM-syndrome is an inherited immunodeficiency disorder with abnormal susceptibility to human papillomavirus (HPV) infection and diseases. We determined safety and immunogenicity to a quadrivalent HPV vaccine in WHIM-syndrome by detection of HPV-specific antibodies and lymphoproliferation. In virus-like-particle (VLP)-ELISA, a WHIM patient showed antibody titers up to 400 for HPV-6/11/16/18, whereas immuno-competent controls developed titers of 6400-25,600. In pseudovirion assays, the patient's neutralization titers ranged from 20 to 400 to the four HPV vaccine types, while titers of 1600-25,600 were detected in healthy vaccinees. Specific proliferation of PBMC of the WHIM patient to the HPV vaccine was demonstrated. This first report on response to HPV vaccination in WHIM-immunodeficiency highlights that patients with WHIM-syndrome, and probably other immunodeficiencies, may benefit from HPV immunoprophylaxis.

• 出版日期2010-7-5