Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia

作者：Shand A W^*; Nassar N; Von Dadelszen P; Innis S M; Green T J

来源：BJOG: An International Journal of Obstetrics and Gynaecology , 2010, 117(13): 1593-1598.

DOI：10.1111/j.1471-0528.2010.02742.x

• Pre-eclampsia
• pregnancy outcome
• vitamin D

Objective To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.
Design Prospective cohort study.
Setting Vancouver, British Columbia, Canada (49 degrees N).
Population Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).
Methods Serum 25OHD concentration measured between 10 and 20 weeks of gestation.
Main outcome measures Pre-eclampsia and composite adverse pregnancy outcomes.
Results Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.
Conclusions Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.

• 出版日期2010-12
• 单位河北医科大学