An eco-compatible multicomponent strategy for the synthesis of new 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles in aqueous micellar medium promoted by thiamine-hydrochloride

作者：Fatma Shahin; Singh Divya; Ankit Preyas; Mishra Priya; Singh Mandavi; Singh Jagdamba^*

来源：Tetrahedron Letters, 2014, 55(14): 2201-2207.

DOI：10.1016/j.tetlet.2014.02.050

• Thiamine hydrochloride
• Cyano acetyl indole
• One-pot
• CTAB
• Michael addition

A thiamine hydrochloride (VB1) accelerated, one-pot synthesis of 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles was achieved via four-component reaction of 3-cyanoacetyl indole, aromatic aldehydes, ammonium acetate, and malononitrile in aqueous micellar conditions by a Knoevenagel condensation reaction followed by Michael-addition, which upon cyclization and dehydration yielded the corresponding product in excellent proportion.

• 出版日期2014-4-2