A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging

作者：Eguchi Haruki^*; Umemura Masanari; Kurotani Reiko; Fukumura Hidenobu; Sato Itaru; Kim Jeong Hwan; Hoshino Yujiro; Lee Jin; Amemiya Naoyuki; Sato Motohiko; Hirata Kunio; Singh David J; Masuda Takatsugu; Yamamoto Masahiro; Urano Tsutomu; Yoshida Keiichiro; Tanigaki Katsumi; Yamamoto Masaki; Sato Mamoru; Inoue Seiichi; Aoki Ichio; Ishikawa Yoshihiro

来源：Scientific Reports, 2015, 5(1): 9194.

DOI：10.1038/srep09194

Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., mu-oxo N, N'bis( salicylidene) ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.

• 出版日期2015-3-17
• 单位RIKEN